An engineer at the BioTis Laboratory (INSERM U1026) in Bordeaux, she provides essential technical support for cellular biology research projects, with expertise in cell culture, confocal microscopy, molecular biology, and biochemistry. Her work focuses on endothelial cells and their interactions with the extracellular matrix, particularly through specialized structures such as podosomes and invadosomes that actively remodel the matrix. She contributes to projects investigating how molecular signals such as TGF-β induce podosome formation in arterial endothelial cells, playing a crucial role in angiogenesis, inflammation, and vascular repair. Using advanced imaging techniques and cell culture models, she supports innovative research aimed at developing recombinant matrix proteins for therapeutic purposes — including restoring vascular wall integrity and inhibiting pathological neovascularization. At BioTis, Isabelle plays a key role in carrying out complex experiments that advance understanding of cellular dynamics in the vascular context, with potential applications in regenerative medicine and extracellular matrix modulation.
