• Home
  • Research Areas
    • Cells
    • Tissues
    • Technologies
  • News
  • Publications
  • People
    • Organizational Chart
    • Researchers
    • Scientific staff
    • Administrative Saff
    • Students
  • Join our Team

Contact

Fabien Kawecki

bottom

Contact

Linkedin biotis-bordeaux

Secretary Email

33 (0)5 57 57 14 88

Bioingénierie Tissulaire (BioTis)       

Physical Address:

Batiment BBS (Bordeaux Biologie Santé), 5e étage

2, rue du Dr Hoffmann Martinot,

33000, Bordeaux, France

Mailing Address:

Université de Bordeaux, Campus Carreire

146, rue Léo Saignat, Case 84,

33076, Bordeaux Cedex, France

Biological Surgical Sutures Made of CAM

Abstract

Reference

Project Leader

Vascular surgical repair, including procedures such as arterial and venous anastomoses, relies heavily on suture materials that provide both mechanical reliability and biocompatibility [1,2]. Current clinical practice predominantly uses synthetic polymers such as polypropylene (Prolene™) or polyglactin (Vicryl™), which exhibit excellent handling properties and mechanical strength [3,4]. However, despite their widespread use, these materials are inherently foreign to the human body and can elicit adverse host responses. Following implantation, synthetic sutures may be subject to inflammatory reactions leading to degradation, encapsulation, or, in severe cases, extrusion [5-9].

These limitations highlight a critical need for new suture materials that combine mechanical performance with improved biological integration. To address this challenge, our research project focuses on developing biological sutures derived entirely from Cell-Assembled extracellular Matrix (CAM). CAM materials, produced by cultured cells without exogenous scaffolds, offer a fully biological composition that has the potential to enhance host acceptance and reduce immune-mediated complications [10,11]. In this project, we engineered CAM-based ribbons and processed them into sutures using hydrated or twisted/dried formats with controlled initial dimensions [12].

▷Hochberg J, Meyer KM and Marion MD 2009 Suture choice and other methods of skin closure Surg. Clin. North Am. 89 627–41

▷Debus E S, Geiger D, Sailer M, Ederer J and Thiede A 1997 Physical, biological and handling characteristics of surgical suture material: a comparison of four different multifilament absorbable sutures Eur. Surg. Res. 29 52–61

▷Schmitz-Rixen T, Storck M, Erasmi H, Schmiegelow P and Horsch S 1991 Vascular anastomoses with absorbable suture material: an experimental study Ann. Vasc. Surg. 5 257–64

▷Calhoun T R and Kitten CM 1986 Polypropylene suture—is it safe? J. Vasc. Surg. 4 98–100

▷Lock A M, Gao R, Naot D, Coleman B, Cornish J and Musson D S 2017 Induction ofimmune gene expression and inflammatory mediator release by commonly used surgical suture materials: an experimental in vitro study Patient Saf. Surg. 11 1–8

▷Dart A J and Dart CM 2017 Suture material: conventional and stimuli responsive Comprehensive Biomaterials II (Elsevier) pp 746–71

▷Ryu K J, Ahn K H and Hong S C 2014 Spontaneous complete migration of suture material after subcuticular continuous suture in cesarean section: a case report BMC Surg. 14 4–6

▷Foster J A, John K B, Castro E and Meisler DM 2000 Blepharoptosis surgery complicated by late suture migration Am. J. Ophthalmol. 130 116–7

▷Lee J, Oh S and Jeon M J 2021 Suture complication rates and surgical outcomes according to the nonabsorbable suture materials used in vaginal uterosacral ligament

suspension: polyester versus polypropylene J. Minim. Invasive Gynecol. 28 1503–7

▷Kawecki F, Gluais M, Claverol S, Dusserre N, McAllister T N and L’Heureux N 2022 Inter-donor variability of extracellular matrix production in long-term cultures of human fibroblasts Biomater. Sci. 10 3935–50

▷Magnan L, Kawecki F, Labrunie G, Gluais M, Izotte J, Marais S, Foulc M P, Lafourcade M and L’Heureux N 2021 In vivo remodeling ofhuman cell-assembled extracellular matrix yarns Biomaterials 273 120815

▷Borchiellini P, Rames A, Roubertie F, L'Heureux N, Kawecki F 2023 Development and characterization of biological sutures made of cell-­assembled extracellular matrix Biofabrication 15, 045018