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Contact

Claudine Boiziau

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Contact

Linkedin biotis-bordeaux

Secretary Email

33 (0)5 57 57 14 88

Bioingénierie Tissulaire (BioTis)       

Physical Address:

Batiment BBS (Bordeaux Biologie Santé), 5e étage

2, rue du Dr Hoffmann Martinot,

33000, Bordeaux, France

Mailing Address:

Université de Bordeaux, Campus Carreire

146, rue Léo Saignat, Case 84,

33076, Bordeaux Cedex, France

Glucose sensors: wireless communication and non-invasive fibrosis measurement

Abstract

Reference

Camille Blanchard

Project Leader

The increase in the prevalence of diabetes is driving research aimed at improving the management of this disease. In this context, continuous glucose monitoring (CGM) implantable systems have been a real innovation that has greatly improved the patient quality of life. However, the accuracy of CGM sensor gradually decreases due to the foreign body reaction (FBR) (Bobrowski and Schuhmann, 2018): after about two weeks, this reaction causes the formation a fibrous capsule that prevents the free diffusion of glucose (Scholten and Meng, 2018). In addition, electrochemical biosensors must be connected trans-cutaneously to communicate the measured glycemia to a processor and their size remains a constraint.

The WEB project aims to offer a technological breakthrough thanks to a dedicated system of implantable electrode-antenna that integrates a glucose biosensor, a power source, and wireless data transmission (Di Trocchio et al., 2025). The system will also be capable of characterizing the surrounding tissue fibrosis, enabling continuous system self-calibration. The strategy chosen for this measurement uses the electrical properties of biological tissues: due to the presence of cell membranes, which act as small electrical insulators, a direct electrical current cannot flow freely through the tissues. The impedance will therefore depend on the cell/extracellular matrix composition and will be higher in fibrous tissue (Fuentes-Vélez et al., 2022; Lewis et al., 2015).

▷Di Trocchio, L., Pérez-Nicoli, P., Bichon, S., Raimbault, V., Lachaud, J.-L., Gounel, S., Dejous, C., Kuhn, A., Boiziau, C., Mano, N., Hemour, S., 2025. Merging bioelectrochemical transducer and antenna functions for continuous monitoring in biological tissues: an innovative volume-saving strategy. Biosensors and Bioelectronics 290, 117970. https://doi.org/10.1016/j.bios.2025.117970

▷Fuentes-Vélez, S., Fagoonee, S., Sanginario, A., Pizzi, M., Altruda, F., Demarchi, D., 2022. Electrical Impedance-Based Characterization of Hepatic Tissue with Early-Stage Fibrosis. Biosensors 12, 116. https://doi.org/10.3390/bios12020116

▷Lewis, N., Lahuec, C., Renaud, S., McAdams, E., Bogonez-Franco, P., Lethias, C., Kellouche, S., Carreiras, F., Pinna, A., Histace, A., Boissiere, M., Pauthe, E., Lagroye, I., Soulier, F., Bernard, S., Binczak, S., Granado, B., Garda, P., Terosiet, M., Goguin, A., Romain, O., 2015. Relevance of impedance spectroscopy for the monitoring of implant-induced fibrosis: A preliminary study. 2015 IEEE Biomedical Circuits and Systems Conference (BioCAS) 1–4. https://doi.org/10.1109/BioCAS.2015.7348399

▷Oliveira, H., Catros, S., Boiziau, C., Siadous, R., Marti-Munoz, J., Bareille, R., Rey, S., Castano, O., Planell, J., Amédée, J., Engel, E., 2016. The proangiogenic potential of a novel calcium releasing biomaterial: Impact on cell recruitment. Acta Biomaterialia 29, 435–445. https://doi.org/10.1016/j.actbio.2015.10.003

▷Scholten, K., Meng, E., 2018. A review of implantable biosensors for closed-loop glucose control and other drug delivery applications. International Journal of Pharmaceutics 544, 319–334. https://doi.org/10.1016/j.ijpharm.2018.02.022


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