• Home
  • Research Areas
    • Cells
    • Tissues
    • Technologies
  • News
  • Publications
  • People
    • Organizational Chart
    • Researchers
    • Scientific staff
    • Administrative Saff
    • Students
  • Join our Team

Contact

Claire Rigothier

bottom

Contact

Linkedin biotis-bordeaux

Secretary Email

33 (0)5 57 57 14 88

Bioingénierie Tissulaire (BioTis)       

Physical Address:

Batiment BBS (Bordeaux Biologie Santé), 5e étage

2, rue du Dr Hoffmann Martinot,

33000, Bordeaux, France

Mailing Address:

Université de Bordeaux, Campus Carreire

146, rue Léo Saignat, Case 84,

33076, Bordeaux Cedex, France

Biofabrication of a 3D perfused glomerular structure

Abstract

Reference

Romane Lesieur

Project Leader

The objective is to recreate a functional 3D cellular organization able to mimic glomerular filtration and to shed light on the roles and interactions of the various cell types involved. This system will also enable the investigation of filtration-related mechanical forces, permselectivity to proteins and solutes, and the effects of therapeutic molecules on cellular behavior. Beyond generating a single microfiber, the project specifically aims to build an interconnected network of glomerular microfibers that more accurately reflects the native microvascular architecture. In the long term, PERFUGLOMS will offer a key tool for understanding filtration mechanisms, advancing the study of kidney diseases, and facilitating the development of new therapeutic strategies and drug-testing platforms.

▷Valverde M.G. et al. Biomimetic models of the glomerulus. Nat Rev Nephrol 18, 241–257 (2022).

▷Dembele M. et al. Models of glomerular filtration barrier: New developments. Med Sci 37, 242–248 (2021).

▷Chrobak K.M., Potter D.R. & Tien J. Formation of perfused, functional microvascular tubes in vitro. Microvascular Research 71, 185–196 (2006).


Collaborator

The PERFUGLOMS project aims to develop a perfusable three-dimensional (3D) glomerular microvascular structure capable of reproducing the complexity of the renal glomerulus function and providing an innovative in vitro model for studying glomerular pathophysiology. Designed using a microfabrication method, these structures consist of a type 1 collagen scaffold, cellularized by endothelial cells, podocytes, and mesangial cells.

Beatrice L'AZOU