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Contact

Dr. Hugo De Oliveira

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Contact

Linkedin biotis-bordeaux

Secretary Email

33 (0)5 57 57 14 88

Bioingénierie Tissulaire (BioTis)       

Physical Address:

Batiment BBS (Bordeaux Biologie Santé), 5e étage

2, rue du Dr Hoffmann Martinot,

33000, Bordeaux, France

Mailing Address:

Université de Bordeaux, Campus Carreire

146, rue Léo Saignat, Case 84,

33076, Bordeaux Cedex, France

4DBR – 4-Deep Brain Reconstruction (H2020)

Abstract

Reference

Charles Handschin

Project Leader

The 4-Deep Brain Reconstruction (4-DBR) project is a Horizon Europe EIC Pathfinder Open initiative that aims to develop new strategies for regenerating damaged brain tissue in neurodegenerative disorders, with an initial focus on Huntington’s disease. The consortium plans to create an implantable 4D bioprinted “reconstructed brain” that reproduces key aspects of human brain architecture, including relevant cell types, vascularisation and functional neuronal networks.

By combining advanced bioprinting, molecular biology and optogenetic approaches, 4-DBR seeks to improve graft survival and integration compared with existing cell and organoid transplantation techniques, and to generate a robust preclinical foundation for future therapies targeting a range of neurodegenerative conditions.


▷[1] Estarellas M, Gomis C, Canals JM. The Evolving Landscape of Stem Cell Therapies for Huntington's Disease. Mol Diagn Ther. 2025 Oct 30. doi: 10.1007/s40291-025-00816-3. Epub ahead of print. PMID: 41168620.


Marie-Laure Stachowicz

Deepshika Arasu

Malou Léa

Collaborator